Relationship between daily dietary fructose intake, body composition and biochemical parameters patients with type 2 diabetes

Authors

  • Sabriye Arslan Gazi University
  • Nevin Şanlıer Gazi University

Keywords:

Diabetes, Fructose, Obesity, High Fructose Corn Syrup, Diet

Abstract

Purpose: This study was carried out to determine the relationship of daily dietary fructose intake with body composition and some biochemical parameters in individuals with diabetes.

Method and material: A total of 156 individuals with diabetes, 53 men and 103 women, between the ages of 30 and 65 ( =51±8.59 years old) participated in the study. Research data was obtained through face-to-face interviews conducted by the researcher using a questionnaire, which included general information, dietary habits, daily food consumption record.

Results: The fructose intake of the men was 13.2±12.09 g/day and that of the women was 13.6±11.10 g/day (p>0.05). The ratios of the daily dietary energy intake from fructose were 7.4±5.56% and 7.4±5.34% in men and women, respectively. It was determined that the individuals consuming the highest levels of fructose (Q4) had higher BMI, waist circumference and average visceral fat, serum VLDL-C, HbA1c levels and lower serum HDL-C levels than the individuals consuming the lowest levels of fructose (Q1). It was observed that Q4 obtain higher levels of energy, carbohydrates and fat than Q1 (p<0.05). Prevalence of obesity was found to be the lowest (59.0%) in the group intake the lowest levels of fructose and the highest (64.1%) in the group intake the highest levels of fructose (p>0.05).

Conclusion: Further studies are needed to develop more specific suggestions regarding fructose intake and to better understand the relationship between fructose intakes, body composition and biochemical parameters in individuals with type 2 diabetes.

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Author Biographies

Sabriye Arslan, Gazi University

M.Sc., Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics

Nevin Şanlıer, Gazi University

Prof. Dr., Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics

References

Aeberli, I., Gerber, P.A., Hochuli, M., Kohler, S., Haile S,R., Gouni-Berthold, I., et al. (2011). Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial. Am J Clin Nutr, 94(2): 479-485.

View Article: DOI: http://dx.doi.org/10.3945/ajcn.111.013540

Bantle, J.P., Wylie-Rosett, J., Albright, A.L., Apovian, C.M., Clark, N.G., Franz, M.J., et al. (2008). Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care, Suppl 1: S61-S78

View Article: DOI: http://dx.doi.org/10.2337/dc08-S061.

Basciano, H., Federico, L., & Adeli, K. (2005). Fructose, insulin resistance, and metabolic dyslipidemia. Nutr Metab, 2(1): 5.

View Article: DOI: http://dx.doi.org/10.1186/1743-7075-2-5.

Bebis Nutrition Data Base Software Data Base. (2004). The German Food Code and Nutrient Data Base (BLS II.3, 1999) with additions from USDA-sr and other sources, İstanbul, Turkey.

Bortsov, A.V., Liese, A.D., Bell, R.A., Dabelea, D., D’Agostino, Jr R.B., Hamman, R.F., et al. (2011). Sugar-sweetened and diet beverage consumption is associated with cardiovascular risk factor profile in youth with type 1 diabetes. Acta Diabetol, 48(4): 275-282.

View Article: DOI: http://dx.doi.org/10.1007/s00592-010-0246-9.

Bray, G.A. (2008). Fructose: should we worry. Int J Obes, 32(Suppl 7): S127-S131.

View Article: DOI: http://dx.doi.org/doi:10.1038/ijo.2008.248.

Chiavaroli, L., Ha, V., Kendall, C.W., & Sievenpiper, J.L. (2014). Is industrial fructose just a marker of an unhealthy dietary pattern? J Hepatol, 61(1): 172-173.

View Article: DOI: http://dx.doi.org10.1016/j.jhep.2014.02.008.

Couch, S.C., Crandell, J.L., Shah, A.S., Dolan, L.M., Merchant, A.T., Liese, A.D., et al. (2013). Fructose intake and cardiovascular risk factors in youth with type 1 diabetes: SEARCH for diabetes in youth study. Diabetes Res Clin Prac, 100(2): 265-271.

View Article: DOI: http://dx.doi.org/10.1016/j.diabres.2013.03.013.

Cozma, A.I., Sievenpiper, J.L., de Souza R.J., Chiavaroli, L., Ha, V., Wang, D.D., et al. (2012). Effect of fructose on glycemic control in diabetes: a systematic review and meta-analysis of controlled feeding trials. Diabetes Care, 35(7): 1611-1620.

View Article: DOI: http://dx.doi.org/10.2337/dc12-0073.

Crapo, P.A., Kolterman, O.G., & Olefsky, J.M. (1980). Effects of oral fructose in normal, diabetic, and impaired glucose tolerance subjects. Diabetes Care, 3(5): 575-82.

Crapo, P.A., Insel, J., Sperling, M., & Kolterman, O.G. (1981). Comparison of serum glucose, insulin, and glucagon responses to different types of complex carbohydrate in noninsulin-dependent diabetic patients. Am J Clin Nutr, 34(2): 184-190.

Feinman, R.D., & Fine, E.J, 2013. Fructose in perspective. Nutr Metab (Lond), 10(1): 45.

View Article: DOI: http://dx.doi.org/10.1186/1743-7075-10-45.

Forshee, R.A., Storey, M.L., Allison, D.B., Glinsmann, W.H., Hein, G.L., Lineback, D.R., et al. (2007). A critical examination of the evidence relating high fructose corn syrup and weight gain. Crit Rev Food Sci Nutr, 47(6): 561-582.

View Article: DOI: http://dx.doi.org/10.1080/10408390600846457.

Gaby, A.R. (2005). Adverse effects of dietary fructose. Altern Med Rev, 10(4): 294-306.

Goran, M.I., Ulijaszek, S.J., & Ventura, E.E. (2013). High fructose corn syrup and diabetes prevalence: a global perspective. Glob Public Health, 8(1): 55-64.

View Article: DOI: http://dx.doi.org/10.1080/17441692.2012.736257.

Hallfrisch, J., Ellwood, K.C., Michaelis, O.E., Reiser, S., O'Dorisio, T.M., & Prather, E.S. (1983). Effects of dietary fructose on plasma glucose and hormone responses in normal and hyperinsulinemic men. J Nutr, 113(9): 1819-1826.

Havel, P.J. (2005). Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev, 63(5): 133-157.

View Article: DOI: http://dx.doi.org/10.1111/j.1753-887.2005.tb00132.x.

Hossain, P., Kawar, B., & El Nahas, M. (2007). Obesity and diabetes in the developing world-a growing challenge. N Engl J Med, 356(3): 213-215.

View Article: DOI: http://dx.doi.org/10.1056/NEJMp068177.

Jameel, F., Phang, M., Wood, L.G., & Garg, M.L. (2014). Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation. Lipids Health Dis, 13: 195.

View Article: DOI: http://dx.doi.org/10.1186/1476-511X-13-195.

Johnson, R.J., Segal, M.S., Sautin, Y., Nakagawa, T., Feig, D.I., Kang, D.H., et al. (2007). Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr, 86(4): 899-906.

Koseler, E. (2011). Farklı miktarlarda tüketilen fruktozun, vücut ağırlığı ve bazı biyokimyasal parametreler üzerine etkisi. MSc thesis, Ankara: Baskent University.

Lamb, M.M., Frederiksen, B., Seifert, J.A., Kroehl, M., Rewers, M., & Norris, J.M. (2015). Sugar intake is associated with progression from islet autoimmunity to type 1 diabetes: the Diabetes Autoimmunity Study in the Young. Diabetologia, 58(9): 2027-2034.

View Article: DOI: http://dx.doi.org/10.1007/s00125-015-3657-x.

Livesey, G., & Taylor, R. (2008). Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies. Am J Clin Nutr, 88(5): 1419-1437.

View Article: DOI: http://dx.doi.org/10.3945/ajcn.2007.25700.

Marriott, B.P., & Cole, N., Lee, E. (2009). National estimates of dietary fructose intake increased from 1977 to 2004 in the United States. J Nutr, 139(6): 1228S-1235S.

View Article: DOI: http://dx.doi.org/10.3945/jn.108.098277.

Mayes, P.A. (1993). Intermediary metabolism of fructose. Am J Clin Nutr, 58(5 Suppl):754-765.

Meyer, K.A., Kushi, L.H., Jacobs, D.R., Slavin, J., Sellers, T.A., & Folsom, A.R. (2000). Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr, 71(4): 921-930.

Neilson, E.G. (2007). The fructose nation. J Am Soc Nephrol, 18(10): 2619-2621.

View Article: DOI: http://dx.doi.org/10.1681/ASN.2007070750.

Park, Y.K., & Yetley, E.A. (1993). Intakes and food sources of fructose in the United States. Am J Clin Nutr, 58(5 Suppl): 737S-747S.

View Article: DOI: http://dx.doi.org10.1681/ASN.2007070750.

Pekcan, G. (2008). Beslenme durumunun saptanması. In: Baysal A (Ed.): Diyet el kitabı. 5th ed. Hatipoğlu Yayınevi, Ankara, pp.97-118.

Petersen, K.F., Laurent, D., Yu, C., Cline, G.W., & Shulman, G.I. (2001). Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans. Diabetes, 50(6): 1263-1268.

View Article: DOI: http://dx.doi.org/10.2337/diabetes.50.6.1263.

Poitout, V., Robertson, R.P. (2008). Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocr Rev, 29(3): 351-366.

View Article: DOI: http://dx.doi.org/10.1210/er.2007-0023.

Rakicioglu, N., Acar, N.T., Ayaz, A., & Pekcan, G. (2012). Yemek ve besin ve fotoğraf kataloğu: Ölçü ve miktarlar. 3th ed. Ata offset publications, Ankara.

Schulze, M.B., Manson, J.E., Ludwig, D.S., Colditz, G.A., Stampfer, M.J., Willett, W.C. et al. (2004). Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA, 292(8): 927-934.

View Article: DOI: http://dx.doi.org/10.1001/jama.292.8.927.

Sheehy, A.M., Coursin, D.B., & Gabbay, R.A. (2009). Back to Wilson and Jungner: 10 good reasons to screen for type 2 diabetes mellitus. Mayo Clin Proc, 84(1): 38-42.

View Article: DOI: http://dx.doi.org/10.1016/S0025-6196(11)60806-9.

Simonson, D.C., Tappy, L., Jequier, E., Felber, J.P., DeFronzo, R.A. (1988). Normalization of carbohydrate-induced thermogenesis by fructose in insulin-resistant states. Am J Physio, 254(2 Pt 1): E201-207.

Stanhope, K.L., & Havel, P.J. (2008). Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. Curr Opin Lipidol, 19(1): 16-24.

View Article: DOI: http://dx.doi.org/10.1097/MOL.0b013e3282f2b24a.

Stanhope, K.L., Schwarz, J.M., Keim, N.L., Griffen, S.C., Bremer, A.A., Graham, J.L., et al. (2009). Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest, 119(5): 1322-1334.

View Article: DOI: http://dx.doi.org/10.1172/JCI37385.

Stanhope, K.L., Bremer, A.A., Medici, V., Nakajima, K., Ito, Y., Nakano, T., et al. (2011). Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women. J Clin Endocrinol Metab, 96(10): E1596-1605.

View Article: DOI: http://dx.doi.org/10.1210/jc.2011-1251.

Stanhope, K.L. (2012). Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome. Annu Rev Med, 63: 329-343.

View Article: DOI: http://dx.doi.org/10.1146/annurev-med-042010-113026.

Stephan, B.C.M., Wells, J.C.K., Brayne, C., Albanese. E., & Siervo, M. (2010). Increased fructose intake as a risk factor for dementia. J Gerontol A Biol Sci Med Sci, 65(8): 809-814.

View Article: DOI: http://dx.doi.org/10.1093/gerona/glq079.

Swarbrick, M.M., Stanhope, K.L., Elliott, S.S., Graham, J.L., Krauss, R.M., Christiansen, M.P., et al. (2008). Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women. B J Nutr, 100(5): 947-952.

View Article: DOI: http://dx.doi.org/10.1017/S0007114508968252.

Tappy, L., Randin, J., Felber, J., Chiolero, R., Simonson, D., Jequier E, et al. (1986). Comparison of thermogenic effect of fructose and glucose in normal humans. Am J Physiol, 250(6 Pt 1): 718-24.

Vos, M.B., Kimmons, J.E., Gillespie, C., Welsh, J., & Blanck, H.M. (2008). Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey. Medscape J Med, 10(7): 160.

Wang, D.D., Sievenpiper, J.L., de Souza, R.J., Chiavaroli, L., Ha, V., Cozma, A.I., et al. (2012). The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr, 142(5): 916-923.

View Article: DOI: http://dx.doi.org/10.3945/jn.111.151951.

White, J.S. (2013). Challenging the fructose hypothesis: new perspectives on fructose consumption and metabolism. Adv Nutr, 4(2): 246-256.

View Article: DOI: http://dx.doi.org/10.3945/an.112.003137.

WHO. (2000). Obesity: preventing and managing the global epidemic. Geneva: World Health Organization.

WHO. (2015). Guideline: Sugars intake for adults and children. Geneva: World Health Organization.

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Published

2016-05-27

How to Cite

Arslan, S., & Şanlıer, N. (2016). Relationship between daily dietary fructose intake, body composition and biochemical parameters patients with type 2 diabetes. Journal of Human Sciences, 13(2), 2642–2655. Retrieved from https://www.j-humansciences.com/ojs/index.php/IJHS/article/view/3737

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Medicine